Background
Since the introduction of erythropoiesis-stimulating agents for the management of
anemia in patients with chronic kidney disease (CKD), intravenous (i.v.) iron has
been universally used, especially with hemodialysis (HD) patients, as their average
daily losses of iron typically exceed the oral absorption of iron. The maintenance i.v.
iron regimens vary widely between countries and even among HD centers of the
same country.
Aim
The aim of this study was to find out if high-dose i.v. iron will be superior to low-dose
i.v. iron for treating anemia in HD patients.
Patients and methods
This study was carried out at HD units of Benha University Hospitals and Benha
Teaching Hospital from March 2019 till September 2019. It was carried out on 100
patients with CKD stage V on HD, who were subdivided into two groups.
Group ?: 50 patients with CKD stage V on HD who were eligible for low-dose i.v. iron
therapy.
Group П: 50 patients with CKD stage V on HD who were eligible for high-dose i.v.
iron therapy.
Results
There was an improvement of hemoglobin, serum ferritin, and transferrin saturation
after treatment with low-dose and high-dose iron therapy. However, the high-dose
iron therapy was associated with a high statistically significant improvement
compared with low-dose iron therapy.
Conclusion
High-dose i.v. iron was superior to low-dose i.v. iron for treating anemia in HD
patients. |