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Dr. afaf abdelkader :: Publications:

Title:
Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats
Authors: hmed Abdeen a , ⁎, Mohamed Aboubakr b , 1, Dina Elgazzar b , c , 1, Mohamed Abdo d, Afaf Abdelkader e, Samar Ibrahim a, Ashraf Elkomy b
Year: 2018
Keywords: Piroxicam Rosuvastatin Gastric ulcer Hepato-renal toxicity Lipid peroxidation Apoptosis
Journal: Biomedicine & Pharmacotherapy
Volume: 110
Issue: Not Available
Pages: 895-905
Publisher: Elsevier
Local/International: International
Paper Link:
Full paper Not Available
Supplementary materials Not Available
Abstract:

Piroxicam (Px) is a non-steroidal anti-inflammatory drug that is widely prescribed in various inflammatory disorders. However, Px is known to induce gastric ulceration and hepato-renal toxicity. Rosuvastatin (ROSV), a member of the statin family, has anti-inflammatory and antioxidant actions independent of its anti-hyperlipi-demic action. Therefore, we investigated the protective effects of ROSV against Px-induced gastric, liver, and kidney injury. Five groups of seven rats each were used; control group, ROSV group (20 mg/kg, given orally), Px group (7 mg/kg, given intraperitoneally), Px+ROSV L (7 and 10 mg/kg, respectively), and Px+ROSV H (7 and 20 mg/kg, respectively) group. The results revealed that Px induced severe gastric mucosal damage expressed by high ulcer index along with significant increases in liver and kidney function parameters including AST, ALT, creatinine, and urea. Disrupted lipid metabolism also was observed in Px-treated animals. Moreover, marked an increase in malondialdehyde (MDA) and decreases in glutathione (GSH) and catalase (CAT) levels along with enhanced activated caspase-3 expression in the gastric, hepatic, and renal tissues following Px-insult suggested a possible involvement of lipid peroxidation in Px-induced gastropathy and hepatorenal toxicity. However, in a dose-dependent manner, ROSV was able to mitigate Px-induced lipid peroxidation and apoptosis in gastric, liver, and kidney tissues.

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