A series of novel scaffolds Thiadiazolyl Piperidine, Thiadiazolyl Piperazine,
thiadiazolidine, Thiadiazolyl thiazole and Thiadiazolyl-imidazole-Thione
were synthesized from cheap, available and biologically active stearic acid.
2-amino-5-heptadecyl 1,3,4-thiadiazole reacts with chloroacetyl chloride and
produced 2-choloro-N-(5-heptadecyl-1,3,4-Thiadiazole-2-yl) acetamide. Which
allowed to react with Piperidine, Piperazine, urea and/or Thiourea and Potassium
thiocyanate, and the latest scaffolds have been synthesized, respectively,
and the structures of these compounds were established by elemental analysis,
MS, IR and 1H-NMR spectral data. The antimicrobial activities of the synthesized
compounds were evaluated in-vitro against strains of gram +ve, gram −ve
bacteria and fungi. Nonionic surfactant were obtained by addition of different
moles of propylene oxide (3,5,7 mole) to the synthesized compounds bearing an
active hydrogen. Physico-chemical and surface properties as well as biodegradability
of the synthesized non-ionic surfactants were evaluated. |
