| You are in:Home/Publications/DBU-Catalyzed transprotection of N-Fmoc-cysteine di- and tripeptides into S-Fm-cysteine di- and tripeptides. | |
Dr. Abdelmotaal Abdelmajeid El-Shiekh Abdelmotaal Abdelmajeid :: Publications: |
|
| Title: | DBU-Catalyzed transprotection of N-Fmoc-cysteine di- and tripeptides into S-Fm-cysteine di- and tripeptides.
|
| Authors: | Alan R. Katritzky, Nader E. Abo-Dya, Abdelmotaal Abdelmajeid, Srinivasa R. Tala, M. S. Amine and |
| Year: | 2010 |
| Keywords: | Not Available |
| Journal: | Org. Biomol. Chem |
| Volume: | 9 |
| Issue: | (2) |
| Pages: | 596–599 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Abdelmotaal Abdelmajeid El-Shiekh Abdelmotaal Abdelmajeid_DBU FULL ARTICLE.pdf |
| Supplementary materials | Not Available |
| Abstract: |
The transprotection of N-Fmoc-cysteine containing di- and tripeptides possessing a free SH group to produce the corresponding S-Fm-cysteine di- and tripeptides bearing a free amino group is accomplished efficiently with DBU in dry THF. The N-Fmoc to S-Fm transformation mechanism is discussed. S-Fm-Cysteine di- and tripeptides readily form amide bonds on coupling with N-(Pg-a-aminoacyl)- benzotriazoles and N-(Pg-a-dipeptidoyl)benzotriazoles to give larger peptides. |
