| You are in:Home/Publications/Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies | |
Dr. Sara Metwally Abdallah Mohamed Abdelsayed :: Publications: |
|
| Title: | Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies |
| Authors: | S Abdelsayed; A Elmetwalli; J Hassan; M O Abdel Monem; A H El-Far; F Ameen; M G Hassan |
| Year: | 2025 |
| Keywords: | Halomonas aquamarina; L-glutaminase; cancer therapy; metabolism; marine biotechnology |
| Journal: | Scientific Reports (Nature Portfolio) |
| Volume: | 15 |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Springer Nature (Scientific Reports) |
| Local/International: | International |
| Paper Link: | |
| Full paper | Sara Metwally Abdallah Mohamed Abdelsayed_Revolutionizing_cancer_treatment_with_Halomonas_Aq (1).pdf |
| Supplementary materials | Not Available |
| Abstract: |
This study explores the potential of Halomonas aquamarina–derived L-glutaminase (L-GLS) as a novel anticancer agent by combining in vitro enzymatic assays and computational analyses. L-GLS was isolated and purified from marine bacterial strains, achieving high specific enzymatic activity and demonstrating optimized functional parameters in terms of pH and temperature. Computational studies support the enzyme’s interaction with cancer-related metabolic pathways, highlighting its promise as a therapeutic strategy by targeting glutamine metabolism in tumor cells. Nature |
