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Dr. Sara Metwally Abdallah Mohamed Abdelsayed :: Publications: |
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| Title: | Citrate-capped AuNPs-induced redox reprogramming modulates the TP53–BAX/BCL2–CASP3 Axis, reinforcing antioxidant defense and promoting apoptotic signaling in liver Cancer |
| Authors: | A Elmetwalli; Sara Abdelsayed; M G Hassan; Ibtisam Aboud Almutairi; Deema Kamal Sabir; Hassnaa Elsherbiny; Ashraf Elsayed |
| Year: | 2026 |
| Keywords: | Gold nanoparticles; Hepatocellular carcinoma; TP53; Apoptosis; Redox reprogramming |
| Journal: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Volume: | 344 |
| Issue: | Part 1 |
| Pages: | 126630 |
| Publisher: | Elsevier |
| Local/International: | International |
| Paper Link: | |
| Full paper | Sara Metwally Abdallah Mohamed Abdelsayed_1-s2.0-S1386142525009370-main.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Gold nanoparticles (AuNPs) capped with citrate were assessed for selective cytotoxicity in HepG2 liver cancer cells compared to normal fibroblasts. AuNPs induced redox reprogramming, affecting TP53, BAX, BCL2, and CASP3 expression, disrupted mitochondrial membrane potential, and enhanced antioxidant defense, leading to apoptosis. These findings suggest potential nanomedicine strategies targeting cancer cell vulnerabilities |
