The present study evaluates the potential antidiabetic and hepatoprotective effects of coriander seed extract (CSE) and garlic extract (GE) in streptozotocin (STZ)-induced diabetes. Thirty rats were separated into five groups Group 1; rats received citrate buffer orally (0.5 ml/kg). Rats in groups 2,3,4,5 were I.P injected with single dose of streptozotocin (50mg/kg). After 72 hours, rats in groups 3, 4 and 5 were received orally with CSE (250 mg/kg), GE (250 mg/kg) and glibenclamide (0.5 mg/kg). These extracts and glibenclamide were given daily for 28 successive days. Compared to control, diabetic rats showed significant increases in glucose, AST, and ALT values and most of their pancreatic sections revealed hypocellularity, degeneration, and necrosis of islets cells with acinar necrosis. Furthermore, hepatocellular degeneration, necrosis, and apoptosis, focal inflammatory cellular infiltration with portal fibrosis were predominant in the diabetic rats. Compared to control, there was significant decrease in area percentage of antinsulin antibodies in the pancreas with significant increase in caspase-3 positive cells and fibrotic area% in the liver of diabetic rats. CSE and GE therapy attenuated both pancreatic and hepatocellular damages induced by STZ with restoration of glucose and liver enzyme values. Furthermore, these extracts significantly increase the number of immunopositive β-cells and significantly decrease area percentage of caspase-3 positive immunoreaction and Masson’s trichrome staining collagen fibers. Both CSE and GE had excellent antidiabetic and hepatoprotective impacts against STZ-induced diabetes probably due to their antiapoptotic and antifibrotic activities; however CSE had more beneficial effects. |
