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Dr. Ghada Mohamed Abdel Khalek Abdel Razik :: Publications:

Title:
Association between inducible nitric oxide synthase-954-G>C and Ex16+14-C>T gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis
Authors: Hamed, Ahmed M.; Naji, Sura M.a; Youssef, Mayada E.b; Nasr, Hend E.c; Shams, Ghada M
Year: 2023
Keywords: Not Available
Journal: Egyptian Journal of Dermatology and Venerology
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Ghada Mohamed Abdel Khalek Abdel Razik_paper5.pdf
Supplementary materials Not Available
Abstract:

Psoriasis is a prevalent disorder of primarily skin and joint affection with a wellknown genetic background and a sophisticated pathogenesis. The inducible nitric oxide synthase (iNOS) gene polymorphisms are unexplored areas of research when it comes to psoriasis. Objectives The aim of the study was to investigate the probable link between iNOS gene polymorphisms (-954 G/C and Ex 16+14C/T) and susceptibility to psoriasis and psoriatic arthritis (PsA). Patients and methods We included three groups of participants: 100 participants each of psoriasis, PsA and healthy controls. Genetic polymorphism analysis was performed utilizing the PCR with the restriction fragment length polymorphism method. Results Genetic analysis of iNOS polymorphism at Ex 16+14C/T revealed significantly increased CT genotype frequency and significantly lower CC genotype frequency in psoriasis (P=0.0011, 0.003, respectively) and PsA patients (P=0.001, P

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