Background: Despite the wide use of saliva-based
measurements in inflammatory,
autoimmune and neoplastic conditions, its use in dermatology is still limited.
Aims: The aims of this study were to assess the serum and salivary levels of interleukin-
1
beta (IL-1β)
and C-reactive
protein (CRP) in patients with acne vulgaris.
Patients/Methods: The study included 84 moderate-to-
severe
acne vulgaris patients,
in addition to 105 healthy control subjects. Serum and salivary levels of CRP and IL-1β
were estimated using enzyme-linked
immunosorbent assay (ELISA) technique.
Results: Using T-test,
the serum and salivary levels of both CRP and IL-1β
in the
patients were significantly higher than the measured levels in the control subjects
(p < 0.001). Using Pearson correlation coefficient, serum and salivary CRP and serum
IL-1β
levels showed significantly positive correlation with GAGS scores (p < 0.001).
The levels of IL-1β
in saliva did not show significant correlation with GAGS scores or
with serum and salivary CRP.
Conclusions: The current study supports the emerging role of saliva as a valid noninvasive
tool for monitoring inflammation and as a reliable and stress-free
tool to evaluate
cytokines and other inflammatory marker levels in acne vulgaris |
