Background: Despite advances in therapy, sepsis is the leading
cause of death in critical care settings, so early diagnosis of sepsis
is a must, so we performed a meta-analysis to compare the
accuracy of presepsin versus CRP and procalcitonin as biomarker
of sepsis. Methods: This analysis performed using MEDLINE,
EMBASE, PubMed and Cochrane to identify all published
randomized, and prospective clinical trials, comparing the
accuracy of Presepsin versus Procalcitonin and CRP in diagnosis
of sepsis. Results: The Database of our meta-analysis included
13 studies with 2679 participants meeting definitive criteria of
sepsis, The pooled sensitivity and of presepsin, procalcitonin and
CRP was 0.84, 0.80, 0.69 respectively which shows that
presepsin is stronger than procalcitonin and CRP, the pooled
specificity of presepsin, procalcitonin, CRP was 0.73, 0.69, 0.68
respectively. The PLR and NLR of presepsin were 2.7 and 0.2,
respectively and of procalcitonin were 2.6 and 0.29, respectively
and of CRP were 2.6 and 0.41, respectively. The DOR of
presepsin, procalcitonin and CRP was 11.8, 8.8, 6.2, respectively.
Conclusions: This study demonstrated that presepsin is a reliable
biomarker of sepsis because of its higher sensitivity and
specificity than procalcitonin and CRP. |
