The Relation Between The Changes In The Gastro-intestinal Bacterial Flora And Degree Of Severity Of Bronchial Asthma In Children:

Mohammed Abdel Hamid El Deeb

Broncial asthma is one of te most common diseases in xildren. It is responsible for a significant proportion of acute and chronic illness in children.Nawadays asthma is considered a chronic inflammatory disease involving many interacting cells that release many inflammatory mediators activating several target cells in the airway. This result in broncocnstriction. Microvascular leakage and oedema. Mucus hypersetion and stimulation of neural reflexes.Changes in gastro-intestinal microflora can exaggerate this in flammatory process in an already asthmatic children leading to increase in the severity of te attacks. It is important to emphasize that these changes don’t induce the asthmatic attacks but only increase the severity of the attacks by many mechanisms.1-Immunological mechanism : mediated by several enzymes and toxins elaborated by these organisms.