Study Of Tumour Necrosis Factor And Interleukin-1 In Familial Mediterranean Fever:

Hala Kamal El-din Nazif

The present study was conducted on 40 subjects, 25 patients fulfiling the diagnostic criteria of FMF serve as a patient group, and 15 normal volunteer subjects as a control group. Of 25 FMF patients, there were 14 patients receiving colchicine treatment. The samples were taken, while 14 patients were in attack and 11 were in remission.All patients & controls were subjected to the following:(1)Full medical history.(2)Clinical Examination.(3)Fasting blood sample was drown from every person and subjected to :1 - Complete blood picture.2 - C-reactive protein(CRP).3 - Serum interleukin-lf3 (IL-1beta).4 - Serum tumour necrosis factor alpha (TNF-alpha).Results of this work were statistically analysed.1 - There was a significant increase in monocyte count in FMF patients compared with healthy subjects.2 - There was a significant increase in CRP serum levels in FMF patients compared with healthy subjects.3 - There was a positive significant correlation between TNF-alpha and CRP serum levels.4 - Serum level of IL-1beta in FMF patients was significantly increased in patient group during acute attacks and in patient group during remissions compared with the healthy controls.5 Serum level of 1L-1beta was significantly increased in patient groupduring acute attacks compared with patient group during remissions.6 - The TNF-alpha serum level in patient group during acute attacks and in patient group during remissions was significantly increased in relation to that of healthy controls.7 - There was a significant increase in TNF-alpha serum level in patient group during acute attacks compared with patient group during remissions.We concluded from this study that :IL-1beta and TNF-alpha serum levels during acute attacks are markedly increased to levels over those of asymptomatic FMF, also IL-1beta and INF-alpha serum levels in asymptomatic FMF patients are increased over those of control group. SOIL-1beta and TNF-alpha play a role in the clinical diagnosis of FMF.