Abstract:
For several decades,
equine physical performance has been a subject of
research;
just
some
studies have
been
directed
for
molecular genetic analyses. To
date,
examines in people
have
reported
several
genes
related with
elite athletic performance
,
while thinks about in horses
are uncommon.
In
our
research
we
aimed
to
illustrate
the
role of
certain genes which
linked with
exercise and training, and have been
revealed
to be functionally relevant for
early performance
assessment
of elite athletic horses.
Ten racing horses (5
Arabian
and 5
T
horoughbred
horses
)
were
s
elected
from equestrian clubs in Cairo Governorate. Firstly, physical parameters
included
(heart rate and
temperature)
were detected. Then,
the
blood samples
obtained
from both groups
before
and
instantly
after tra
ining
from trained horses. Quantitative real time PCR used to measure
HIF
1
α, VEGFα and MCT4
gene expression. Our
results
reported
a
considerable
increase in
HIF
1
α, VEGFα and MCT4
gene expression after training in trained
horses.
The
results
determine
d
the
pivotal
role of
HIF
1
α, VEGFα and MCT4
in exercise
and their important effect
on
equine
performance during hypoxic training.
In conclusion,
t
his study
interprets
underlying molecular responses
to exercise and training adaptations in equine blood and
how
these
responses
affect
on system
-
wide physiological
performance.
B
iology of the HIF
1
pathway a
nd
other related genes affecting
horse
performance
have seen great
interest
.
Despite late
great evolution
in understanding the atomic instruments of the HIF pathw
ay because of
its
activity,
several
important questions
still
need
ed
to be answered
. |
