Methods: A comparative cross-sectional study was
conducted at the Departments of Clinical Pathology
and Internal Medicine, Faculty of Medicine, Benha
University, Benha, Egypt from October 2009 to
December 2010. Sixty adult patients with T2DM
were divided into 2 groups: Group B and Group
C and Group A as the control group. All subjects
evaluation of insulin sensitivity (Homeostasis Model
Assessment of Insulin Resistance [HOMA-IR]), and
blood samples for estimation of fasting blood glucose
(FBG), glycosylated hemoglobin A1c (HbA1c) and
serum insulin, urea, creatinine, C-reactive protein
(CRP), and MBL.
Results: All patients had significantly increased FBG,
serum insulin, HOMA-IR index, serum CRP and
MBL levels compared with the control group, with
significantly higher levels in Group C. Levels of
HbA1c, serum urea, and creatinine were significantly
higher in patients than controls. There was a positive
significant correlation between serum MBL and
FBG, HOMAIR index, serum urea, creatinine, and
CRP levels. The receiver operating characteristics
curve analysis in infectious cases revealed high FBG,
HOMA-index and serum levels of HbA1c, CRP, and
MBL, while regression analysis defined elevated serum
MBL levels as a significant independent predictor for
the presence of infection.
Conclusion: Elevated serum MBL in T2DM patients
indicated a possible poor diabetic control and bad
progression of the disease with possibility of the
presence, or development of diabetic nephropathy
especially in combination with elevated serum CRP. |
