Anticoagulant rodenticides have been used in controlling rodents in Egypt and all over the world.The aim of this work was to study the effect ¼ and ‘l LD50 values of Bromadiolone (Broma) or
Chlorophacinone (Chloro) on some biological aspects of the albino rat. The LD50 value was estimated as 1.12
mg/kg for Broma and 6.31 mg/kg for Chloro, Results revealed that The Pregnancy period significantly increased
under the following treatment order: Broma Y4>Broma /)> Chloro ¼ > Chioro Y10 All treatments showed drastic
weight reduction for fetus when their mothers were dissected after 9’ and 180 gestational day. Also similar
responses were recorded at 2, 5 and 10 weeks age. The time to eye open and to hair coat were delayed
significantly for all tested treatments. There were significant reductions in all tested treatments in the number
of new born. The time to death of new born rat ranged from 3.87 to 27 days with the application of Chloro 1/ia
and Broma ¼, respectively. The histological studies on liver showed dilation of central and portal vein,
congestion with lymphocytic infiltration and necrosis, while in kidney showed degenerative changes with
necrobiosis in the lining epithelial cell of renal tubules, congestion in the glomerular tuft of the hypertrophied
glomeruli, necrosis in lining epithelial cells and degeneration in the renal tubules. Biochemical studies showed
increasing in enzymes.
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