Abstract:
Objective: The aim is to investigate the effectiveness of intensive dynamic exercises on the oxidative status in patients with primary fibromyalgia (FM) and to explore the importance of these effects on the outcome of FM. Methods: We measured levels of stress oxidants (protein carbonyls, nitric oxide and thiobarbituric acid reactive substances) and antioxidant parameters (thiols and catalase) in blood samples from 40 FM patients and from healthy control (n=25) at presentation and after 12 weeks of intensive exercise program that is comprised of aerobic and strengthening exercises(lasting one hour three times per week). In the patients, pain was assessed using the visual analog scale (VAS), tender points count (TP), the fibromyalgia impact questionnaire (FIQ) and the Beck depression inventory (BDI) were undertaken at presentation and after 12 weeks of exercise therapy. Results: At presentation, the serum levels of the oxidative stress parameters were significantly higher (p |
